Contact the veterinarian if the pet has abdominal pain, tenderness, or discomfort; bloody, black or tarry stools or blood in vomit; unexplained weight gain; water retention; fatigue or lethargy; skin rash; itching; yellowing of eyes; unusual bruising or bleeding as these symptoms could indicate serious side effects. If any of the following serious side effects occur, stop giving Previcox and seek emergency veterinary medical attention; an allergic reaction (difficulty breathing; swelling of the lips; tongue or face; hives). Other less serious side effects may occur. Continue giving Previcox and talk to your veterinarian if your pet experiences flatulence or diarrhea; dizziness; headache; or insomnia. Other side effects may also occur. Talk to your veterinarian about any side effect that seems unusual or bothersome to your pet.
While yucca is definitely a safer alternative to synthetic steroids, it should be used in moderation. It should be used to treat a specific condition rather than for everyday, regular use. If it needs to be used over a longer timeframe, make sure to give your dog a couple of days off every week from yucca. Too much yucca can irritate the digestive tract and may reverse its benefits, according to Herbs for Pets. ( Dosing for the dried and powdered root is a 1/2 teaspoon per pound of food. But check with your holistic vet if you are ever unsure.)
As a glucocorticoid , the lipophilic structure of prednisolone allows for easy passage through the cell membrane where it then binds to its respective glucocorticoid receptor (GCR) located in the cytoplasm. Upon binding, formation of the GC/GCR complex causes dissociation of chaperone proteins from the glucocorticoid receptor enabling the GC/GCR complex to translocate inside the nucleus. This process occurs within 20 minutes of binding. Once inside the nucleus, the homodimer GC/GCR complex binds to specific DNA binding-sites known as glucocorticoid response elements (GREs) resulting in gene expression or inhibition. Complex binding to positive GREs leads to synthesis of anti-inflammatory proteins while binding to negative GREs block the transcription of inflammatory genes.