Hepatic Lipidosis Most common form of severe liver disease in cats. Most often seen in obese cats suddenly subjected to dietary deprivation. May also be associated with diabetes mellitus, drug injury and toxicity. Thedisease seems to result from the sudden mobilisation of the bodies fat stores which quickly overwhelms the liver's ability to process the raw fat into useful nutrients. The fat accumulates in the liver rapidly and causes acute liver failure. The end result is a swollen, greasy liver which is fragile and yellow to see. The cats present with complete lack of appetite and many signs of acute liver failure. Treatment is based on the provision of a highly nutritious diet to provide the energy required to run the body, stop the ongoing mobilisation of the fat stores, and drive the liver to decrease the fatty accumulation in the liver. Treatment is difficult and a long process.
To prevent treatment-induced postinflammatory hyperpigmentation, therapies that cause irritation or inflammation should be avoided. When prescribing a retinoid, physicians should start at lower concentrations and titrate up as tolerated. It is best to begin with infrequent dosing (., twice weekly to every other day), and to choose more tolerable formulations, such as creams over gels. Examples of topical retinoids include adapalene % (Differin), tretinoin (Retin-A), and tazarotene (Tazorac). 37 , 49 Benzoyl peroxide can be drying and irritating; using lower concentrations (less than 5%) can limit irritation and subsequent postinflammatory hyperpigmentation. For patients presenting with acne and postinflammatory hyperpigmentation, azelaic acid 20% cream (Azelex), azelaic acid 15% gel (Finacea), topical retinoids, and chemical peels may be helpful in doses that do not cause irritation or inflammation. 37 , 38 , 42 – 45 , 50 If treatment with topical agents is unsuccessful, physicians may consider prescribing systemic antibiotics, hormonal therapies such as spironolactone (Aldactone) or oral contraceptives, or isotretinoin for recalcitrant cases.
Dermatology is the medical speciality which manages skin disease. This is a community based service which can deal with % of skin problems without the need to go to a major hospital setting. Management can involve treatments which range from simple advice and information to drug treatments and surgery. If light treatment is recommended then we will arrange onward referral for you. As GP specialists we have considerable knowledge and years of experience in dermatology. The service is also supported by consultant dermatologists and nurse specialists.